internal Journal for ImmunoTherapy of Cancer, 2018, doi:10.1186/s40425-018-0360-8 Fonts Conformance level of PDF/A standard %PDF-1.4 24 0 obj conformance A reference to the original document from which this one is derived. Adobe PDF Schema PD-1

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It is a minimal reference; missing components can be assumed to be unchanged. endobj PDF/A ID Schema AuthorInformation stPart Specifies the types of editor information: name and ORCID of an editor. Integer seriesEditorInfo Springer Nature ORCID Schema Gives the ORCID of a series editor. 2018-06-18T13:18:09+02:00 name Check for active clinical trials using this agent. Text

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<> XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents). Bag SeriesEditorInformation

Text Text internal xmpTPg Trapped Series editor information: contains the name of each series editor and his/her ORCID identifier.

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To this internal editor http://ns.adobe.com/pdfx/1.3/ An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. converted to PDF/A-2b Text CD73 Amendment of PDF/A standard 2018-06-08T06:44:02+08:00 CD39

Adenosine is often overproduced by cancer cells and plays a key role in immunosuppression.

SourceModified Targeting adenosine for cancer immunotherapy Leisha A. Emens A2AR antagonist 1 is a potent A2AR (Adenosine A2A Receptor) antagonist with Ki values of 4 nM and 264 nM for A2AR and A1R, respectively. Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) 1 0 obj Robert D. Leone Abundant extracellular adenosine can then bind to the A2A receptor resulting in a G s-protein coupled response, resulting in the accumulation of intracellular cAMP, which functions primarily through protein kinase A to upregulate inhibitory cytokines such as transforming growth factor-beta (TGF-β) and inhibitory receptors (i.e., PD-1).

Gives the name of an author. A structure containing the characteristics of a font used in a document XMP Paged-Text EditorInformation PlateNames ID of PDF/X standard S8575: A2AR antagonist 1. amd http://springernature.com/ns/xmpExtensions/2.0/seriesEditorInfo/ A name object indicating whether the document has been modified to include trapping information

internal It binds to A2A receptors with a Ki of 3.54 nmol/L and demonstrates a greater than 50-fold selectivity for the A2A receptor over other adenosine receptor subtypes. <>/XObject<>/ProcSet[/PDF/Text/ImageC/ImageB/ImageI]/ColorSpace<>/Font<>/Properties<>>>/Thumb 23 0 R/MediaBox[0 0 595.276 790.866]/Annots[24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R 37 0 R 38 0 R 39 0 R 40 0 R 41 0 R 42 0 R]/Rotate 0>> seriesEditor http://ns.adobe.com/xap/1.0/sType/Font# endobj Both global and NK-cell-specific conditional deletion of A2AR enhanced proportions of terminally mature NK cells at homeostasis, following reconstitution, and in the tumor microenvironment.



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DerivedFrom URI orcid Conformance level of PDF/X standard authorInfo A structure containing the characteristics of a font used in a document. internal Company creating the PDF endobj Part B Specifies the types of series editor information: name and ORCID of a series editor. URI http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ GTS_PDFXVersion <, Journal for ImmunoTherapy of Cancer, 2018, doi:10.1186/s40425-018-0360-8, Targeting adenosine for cancer immunotherapy. Text http://ns.adobe.com/xap/1.0/t/pg/ 10.1186/s40425-018-0360-8 http://springernature.com/ns/xmpExtensions/2.0/editorInfo/ Gives the ORCID of an author. Bag EditorInformation http://springernature.com/ns/xmpExtensions/2.0/ Keywords: Adenosine, A2a receptor, Checkpoint blockade, PD-1, Immunotherapy, CD39, CD73, CTLA-4 Background The ability to regulate the strength and duration of an im-mune response is a critical aspect of immunity.

2018-06-18T13:18:09+02:00 <>stream InstanceID Bag AuthorInformation Specifies the types of author information: name and ORCID of an author. Identifies a portion of a document.

http://ns.adobe.com/xap/1.0/mm/ 2018-06-08T06:57:04+08:00 pdfx For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced.

For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original.

Gives the ORCID of an editor. internal

hypoxia-CD39-CD73-A2aR pathway have great promise for further improving clinical outcomes in cancer patients. http://ns.adobe.com/xap/1.0/sType/Part# pdf external xmpMM name