internal Journal for ImmunoTherapy of Cancer, 2018, doi:10.1186/s40425-018-0360-8 Fonts Conformance level of PDF/A standard %PDF-1.4 24 0 obj conformance A reference to the original document from which this one is derived. Adobe PDF Schema PD-1
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It is a minimal reference; missing components can be assumed to be unchanged. endobj PDF/A ID Schema AuthorInformation stPart Specifies the types of editor information: name and ORCID of an editor. Integer seriesEditorInfo Springer Nature ORCID Schema Gives the ORCID of a series editor. 2018-06-18T13:18:09+02:00 name Check for active clinical trials using this agent. Text
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Adenosine is often overproduced by cancer cells and plays a key role in immunosuppression.
SourceModified Targeting adenosine for cancer immunotherapy Leisha A. Emens A2AR antagonist 1 is a potent A2AR (Adenosine A2A Receptor) antagonist with Ki values of 4 nM and 264 nM for A2AR and A1R, respectively. Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) 1 0 obj Robert D. Leone Abundant extracellular adenosine can then bind to the A2A receptor resulting in a G s-protein coupled response, resulting in the accumulation of intracellular cAMP, which functions primarily through protein kinase A to upregulate inhibitory cytokines such as transforming growth factor-beta (TGF-β) and inhibitory receptors (i.e., PD-1).
Gives the name of an author. A structure containing the characteristics of a font used in a document XMP Paged-Text EditorInformation PlateNames ID of PDF/X standard S8575: A2AR antagonist 1. amd http://springernature.com/ns/xmpExtensions/2.0/seriesEditorInfo/ A name object indicating whether the document has been modified to include trapping information
internal It binds to A2A receptors with a Ki of 3.54 nmol/L and demonstrates a greater than 50-fold selectivity for the A2A receptor over other adenosine receptor subtypes. <>/XObject<>/ProcSet[/PDF/Text/ImageC/ImageB/ImageI]/ColorSpace<>/Font<>/Properties<>>>/Thumb 23 0 R/MediaBox[0 0 595.276 790.866]/Annots[24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R 37 0 R 38 0 R 39 0 R 40 0 R 41 0 R 42 0 R]/Rotate 0>> seriesEditor http://ns.adobe.com/xap/1.0/sType/Font# endobj Both global and NK-cell-specific conditional deletion of A2AR enhanced proportions of terminally mature NK cells at homeostasis, following reconstitution, and in the tumor microenvironment.
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DerivedFrom URI orcid Conformance level of PDF/X standard authorInfo A structure containing the characteristics of a font used in a document. internal Company creating the PDF endobj Part B Specifies the types of series editor information: name and ORCID of a series editor. URI http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ GTS_PDFXVersion <, Journal for ImmunoTherapy of Cancer, 2018, doi:10.1186/s40425-018-0360-8, Targeting adenosine for cancer immunotherapy. Text http://ns.adobe.com/xap/1.0/t/pg/ 10.1186/s40425-018-0360-8 http://springernature.com/ns/xmpExtensions/2.0/editorInfo/ Gives the ORCID of an author. Bag EditorInformation http://springernature.com/ns/xmpExtensions/2.0/ Keywords: Adenosine, A2a receptor, Checkpoint blockade, PD-1, Immunotherapy, CD39, CD73, CTLA-4 Background The ability to regulate the strength and duration of an im-mune response is a critical aspect of immunity.
2018-06-18T13:18:09+02:00 <>stream InstanceID Bag AuthorInformation Specifies the types of author information: name and ORCID of an author. Identifies a portion of a document.
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hypoxia-CD39-CD73-A2aR pathway have great promise for further improving clinical outcomes in cancer patients. http://ns.adobe.com/xap/1.0/sType/Part# pdf external xmpMM name